When his father dies, Peter Gaulke inherits "Strange Wilderness," dad's TV show about animals. After ratings plummet and the show is canceled, we watch a long flashback to see its demise. The studio head gives the show two more weeks. An old friend brings a story about Bigfoot in Ecuador, so a long road trip ensues with stops along the way and enough problems, misjudgments, and deaths to sink a less intrepid band. Peter's team faces competition from a better-funded and more practiced set of rivals. Who will find Bigfoot first, and will they get it on tape and save the show? Can Peter make dad proud?

A businessman sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester rather naughtily figures out a way to genetically enlarge shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea...